{"id":4727,"date":"2021-12-07T10:58:00","date_gmt":"2021-12-07T10:58:00","guid":{"rendered":"http:\/\/unchainedlabs.sheldon.com\/?page_id=4727"},"modified":"2022-11-09T23:16:13","modified_gmt":"2022-11-09T23:16:13","slug":"particle-analysis-identification","status":"publish","type":"page","link":"https:\/\/unchainedlabs.com\/jp\/particle-analysis-identification\/","title":{"rendered":"Particle analysis &#038; identification"},"content":{"rendered":"\n<h1>\n\t\tabout Unchained Labs\n\t<\/h1>\n\t<ul>\n<li><a href=\"#problem\">Problem<\/a><\/li>\n<li><a href=\"#solution\">Solution<\/a><\/li>\n<li><a href=\"#proof\">Proof<\/a><\/li>\n<li><a href=\"#hound\">Hound<\/a><\/li>\n<\/ul>\n<h4>\n\t\tThe Problem \n\t<\/h4>\n\t<p>Particulate matter is highly regulated in injectable drugs, including monoclonal antibodies and recombinant protein drug products. Problematic particles in these drugs include protein aggregates, excipients and formulation components, or process-related contaminants like plastics, cellulose fibers, or metals.<\/p>\n<p>Most particle\u00a0identification tools are limited to the types of materials they can identify. FTIR can identify protein aggregates and plastics but can&#8217;t handle metals or aqueous suspensions &#8211; which includes almost all protein-based drugs. SEM-EDS is good at identifying metals but not much else. Morphology-based particle identification\u00a0techniques like flow imaging or microscopy can provide a guess at particle composition based on appearance but can&#8217;t confirm chemical or elemental make-up. This means you need at least two, if not more of these instruments to handle any possible problem particle.<\/p>\n<h4>\n\t\tThe right tool for the job\n\t<\/h4>\n\t<p><a href=\"https:\/\/unchainedlabs.com\/jp\/hound\">Hound <\/a>is the only particle analysis\u00a0tool that combines <a href=\"https:\/\/unchainedlabs.com\/jp\/microscopic-particle-analysis\">microscopy<\/a>, <a href=\"https:\/\/unchainedlabs.com\/jp\/raman-microscopy\/\">Raman spectroscopy<\/a>, and <a href=\"https:\/\/unchainedlabs.com\/jp\/laser-induced-spectroscopy-libs\/\">Laser-Induced Breakdown Spectroscopy (LIBS) <\/a>to count, size, and ID particles by their chemical or elemental fingerprints. Raman spectroscopy is primo for identifying organic, inorganic, and proteinaceous compounds including plastics and cellulose fibers. If you&#8217;re dealing with metals and other inorganic compounds, quickly switch over to LIBS. With all these capabilities packed into one particle identification\u00a0instrument, Hound is the one-stop shop for identifying your particles in minutes.<\/p>\n<h4>\n\t\tThe proof\n\t<\/h4>\n<h5>\n\t\tCatch protein aggregation\n\t<\/h5>\n\t<p>Identifying protein aggregates is crucial when working with monoclonal antibody and recombinant protein drug products. Raman 532 nm is perfect for identifying proteins when aggregates show up &#8211; even allowing you to differentiate between different proteins based on their Raman spectra. <\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/unchainedlabs.com\/jp\/wp-content\/uploads\/2021\/12\/Proof_Catch-protein-aggregation_r4.png\" alt=\"Proof_Catch protein aggregation_r4\" itemprop=\"image\" height=\"1507\" width=\"2560\" title=\"Proof_Catch protein aggregation_r4\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tTrack down any contaminant\n\t<\/h4>\n\t<p>Particle analysis is a breeze with <a href=\"https:\/\/unchainedlabs.com\/jp\/hound\">Hound&#8217;s <\/a>combo of Raman lasers and LIBS &#8211; even if you have multiple unknowns in your sample. Raman 785 nm identified one of three unknown particles as cellulose. Raman 532 nm was used to identify a second particle as polystyrene. A third particle was identified as copper after LIBS analysis. Within minutes all three visible particles were identified, so a quick pivot could be made to finding their source. If your sample has a ton of particles, Hound can automatically find, count, and identify them all without you having to babysit the instrument.<\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/unchainedlabs.com\/jp\/wp-content\/uploads\/2021\/12\/Hound_graph-1_v4.png\" alt=\"Hound_graph 1_v4\" itemprop=\"image\" height=\"955\" width=\"1631\" title=\"Hound_graph 1_v4\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/unchainedlabs.com\/jp\/wp-content\/uploads\/2021\/12\/Hound_graph-2_v4-1.png\" alt=\"Hound_graph 2_v4\" itemprop=\"image\" height=\"955\" width=\"1631\" title=\"Hound_graph 2_v4\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/unchainedlabs.com\/jp\/wp-content\/uploads\/2021\/12\/Hound_graph-3_v4.png\" alt=\"Hound_graph 3_v4\" itemprop=\"image\" height=\"956\" width=\"1655\" title=\"Hound_graph 3_v4\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tCustomize to your process\n\t<\/h4>\n\t<p><a href=\"https:\/\/unchainedlabs.com\/jp\/hound\">Hound <\/a>not only comes with a large, built-in reference database but it also allows you to create custom references to fit your unique process. Aluminum can come from many sources, but this particle was tracked back to the Wheaton crimp caps used to seal this drug product based on the unique peaks identified when compared to an aluminum standard. The ability to create a custom database that allows for the specificity of the spectra makes it that much easier to trace contaminants back to the source.<\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/unchainedlabs.com\/jp\/wp-content\/uploads\/2021\/12\/Proof_Customize-your-process_r3.png\" alt=\"Proof_Customize your process_r3\" itemprop=\"image\" height=\"1260\" width=\"2035\" title=\"Proof_Customize your process_r3\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/unchainedlabs.com\/jp\/wp-content\/uploads\/2021\/12\/Proof_Customize-your-process_Wheaton_r3.png\" alt=\"Proof_Customize your process_Wheaton_r3\" itemprop=\"image\" height=\"1260\" width=\"2039\" title=\"Proof_Customize your process_Wheaton_r3\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/unchainedlabs.com\/jp\/wp-content\/uploads\/2021\/12\/Hound_front_open_transparent_shadow-1.jpg\" alt=\"Hound_front_open_transparent_shadow\" title=\"Hound_front_open_transparent_shadow\" itemprop=\"image\"\/>\n\t\t\t<h3>Hound<\/h3>\t\t\t\n\t\t\t\t<p>Hound is the only particle analysis\u00a0tool out there that combines <a href=\"https:\/\/unchainedlabs.com\/jp\/microscopic-particle-analysis\">microscopy<\/a>, <a href=\"https:\/\/unchainedlabs.com\/jp\/raman-microscopy\/\">Raman <\/a>and <a href=\"https:\/\/unchainedlabs.com\/jp\/laser-induced-spectroscopy-libs\/\">Laser-Induced Breakdown Spectroscopy<\/a> (LIBS) to count, size, and ID particles by their chemical or elemental fingerprints. With all these capabilities packed into one instrument, Hound gathers up all the info you need about your particles in minutes.<\/p>\n\t\t\t<a href=\"https:\/\/unchainedlabs.com\/jp\/hound\" target=\"_self\" role=\"button\" aria-label=\"Meet Hound\" rel=\"noopener\">\n\t\t\t\t\t\t\tMeet Hound\n\t\t<\/a>\n<h2>\n\t\tWant more info?\n\t<\/h2>\n\t<p>Want to learn more about how Hound provides specific and customizable particle identification for organic, inorganic, proteinaceous, and metallic materials?<\/p>\n\t\t\t<a href=\"https:\/\/unchainedlabs.com\/jp\/contact-us\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tGet In touch\n\t\t\t\t\t<\/a>\n<h2>\n\t\trelated applications\n\t<\/h2>\n\t\t\t<a href=\"https:\/\/unchainedlabs.com\/jp\/protein-quantification\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tProtein Quantification\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/unchainedlabs.com\/jp\/quantification-aggregation\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tQuantification &#038; Aggregation\n\t\t\t\t\t<\/a>\n\n","protected":false},"excerpt":{"rendered":"<p>about Unchained Labs Problem Solution Proof Hound The Problem Particulate matter is highly regulated in injectable drugs, including monoclonal antibodies and recombinant protein drug products. Problematic particles in these drugs include protein aggregates, excipients and formulation components, or process-related contaminants like plastics, cellulose fibers, or metals. Most particle\u00a0identification tools are limited to the types of&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4727","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Particle Analysis &amp; Identification | Unchained Labs<\/title>\n<meta name=\"description\" content=\"Learn the different methods for particle analysis and identification and why combining Raman spectroscopy, microscopy, and LIBS lets you ID any particle.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/unchainedlabs.com\/jp\/particle-analysis-identification\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Particle Analysis &amp; 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