{"id":13570,"date":"2023-01-17T01:00:43","date_gmt":"2023-01-17T01:00:43","guid":{"rendered":"https:\/\/unchainedlabs.com\/jp\/?p=13570"},"modified":"2023-10-05T07:17:08","modified_gmt":"2023-10-05T07:17:08","slug":"unchained-labs-finds-the-lenti-leprechaun-at-the-end-of-the-rainbow","status":"publish","type":"post","link":"https:\/\/unchainedlabs.com\/jp\/unchained-labs-finds-the-lenti-leprechaun-at-the-end-of-the-rainbow\/","title":{"rendered":"Unchained Labs finds the Lenti Leprechaun at the end of the rainbow"},"content":{"rendered":"

January 17, 2023 \u2013 Pleasanton, CA \u2013 Unchained Labs<\/a>, the life sciences company that\u2019s all about getting biologics and gene therapy researchers the right tool for the job, launched Leprechaun<\/a> today \u2013 the first platform to simultaneously measure lentivirus titer and structure at any step in the development process \u2013 no matter how crude or messy the sample is.<\/p>\n

Lentiviruses (Lenti) are big, beastly viral vectors used to permanently fix the genome of cells that cause disease or program immune cells to track down and wipe out cancer. Researchers need to know how many Lenti\u2019s they\u2019ve made and confirm that they have the right structure. Most researchers use single-component assays like ELISA to measure the capsid titer or PCR to measure the genome titer. Both assays require Lenti to be broken apart, provide only one piece of the puzzle and neither confirms if they ever had the right structure.<\/p>\n

Leprechaun brings to light more information about Lenti titer and structure than any tool out there \u2013 from samples straight out of cell culture to the final cleanup step and anything in between. Using a combination of antibody capture, fluorescence, and interferometry, researchers can see how many Lenti particles were assembled correctly by confirming they are the right size, have a capsid and that surface proteins are on board. From the same assay they can see if contaminants like improperly assembled Lenti\u2019s, aggregates, soluble capsid proteins, or extracellular vesicles are hanging around. All this info comes from 25 \u03bcL or less of their sample.<\/p>\n

\u201cUntil now, measuring a meaningful Lenti titer was almost impossible and full of confusion and frustration.\u201d said Taegen Clary, SVP of Marketing at Unchained Labs. \u201cLeprechaun hands over the treasure that researchers have been looking for \u2013 the ability to see if their Lenti\u2019s are properly assembled and if they have enough of them to create the next life-altering cell-based gene therapy.\u201d<\/p>\n

About Unchained Labs<\/strong><\/p>\n

Here\u2019s the deal. We\u2019re all about helping biologics and gene therapy researchers break free from tools that just don\u2019t cut it. Unleashing problem-tackling solutions that make a huge difference in the real science they do every day. That\u2019s our mantra, our promise and we own it. We\u2019re located in Pleasanton, CA and can be found online at unchainedlabs.com\/jp<\/a>.<\/p>\n

\u00a0<\/strong>Contact:<\/strong><\/p>\n

Taegen Clary
\nSVP of Marketing, Unchained Labs
\ntaegen.clary@unchainedlabs.com\/jp<\/a>
\n925.587.9806<\/p>\n

Download PDF of the press release<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

January 17, 2023 \u2013 Pleasanton, CA \u2013 Unchained Labs, the life sciences company that\u2019s all about getting biologics and gene therapy researchers the right tool for the job, launched Leprechaun today \u2013 the first platform to simultaneously measure lentivirus titer and structure at any step in the development process \u2013 no matter how crude or…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,121],"tags":[],"class_list":["post-13570","post","type-post","status-publish","format-standard","hentry","category-uncategorized","category-news"],"acf":[],"yoast_head":"\nUnchained Labs finds the Lenti Leprechaun at the end of the rainbow - unchainedlabs<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/unchainedlabs.com\/jp\/unchained-labs-finds-the-lenti-leprechaun-at-the-end-of-the-rainbow\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Unchained Labs finds the Lenti Leprechaun at the end of the rainbow - 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