{"id":14094,"date":"2023-07-17T04:30:21","date_gmt":"2023-07-17T04:30:21","guid":{"rendered":"https:\/\/unchainedlabs.com\/jp\/?p=14094"},"modified":"2023-10-05T07:17:07","modified_gmt":"2023-10-05T07:17:07","slug":"unchained-labs-goes-all-in-on-lipid-nanoparticles","status":"publish","type":"post","link":"https:\/\/unchainedlabs.com\/jp\/unchained-labs-goes-all-in-on-lipid-nanoparticles\/","title":{"rendered":"Unchained Labs goes all in on Lipid Nanoparticles, acquires Blacktrace Holdings!"},"content":{"rendered":"

July 17, 2023 \u2013 Pleasanton, CA \u2013 Unchained Labs<\/a>, the life sciences company that\u2019s all about getting biologics and gene therapy researchers the right tools for the job, acquired Blacktrace Holdings today. For decades, Blacktrace\u2019s Dolomite microfluidics have been helping scientists with complex workflows. More recently, their Particle Works<\/a> solutions are changing the game on how researchers screen lipid nanoparticle (LNP) formulations and rapidly scale-up the winners \u2013 with the same methods and microfluidic chip.\u00a0<\/span><\/p>\n

We all know LNPs make great vaccines, but they are coming on strong in gene therapy. To be effective, LNPs need to be the right size and have the right make up to get inside cells and deliver their payload. Making the perfect LNP means finding the best formulation, which requires a ton of trial and error. Researchers need to figure out the right lipid mixture, the right lipid to payload ratio and dial in the different flow rates needed to mix it all together \u2013 a process that can feel like it takes forever.\u00a0<\/span><\/p>\n

That\u2019s where the Particle Works LNP solutions come to the rescue. ALiS (Automated Library Synthesis System)<\/a> is the only high throughout LNP formulation screening solution out there. In a single, six-hour experiment, ALiS creates 96 unique, 200 \u03bcl LNP formulations that can be screened for size and encapsulation, and then moved to assays that check for payload expression. Once the best formulation is found, ANP (Automated Nanoparticle System)<\/a> takes over to fine-tune the ALiS method, and using the same reusable chip can scale it up to over 50 liters in 24 hours. If this wasn\u2019t enough, a GMP production solution is currently in the works and Unchained Labs plans to finish it and make it available ASAP.\u00a0<\/span><\/p>\n

\u201cWe have spent the past two years developing and providing a better way to make LNPs,\u201d said Mark Gilligan, CEO at Blacktrace Holdings. \u201cUnchained Labs is committed to providing LNP researchers with tailor-made solutions and I can\u2019t think of a better home for our Particle Works solutions.\u201d\u00a0<\/span><\/p>\n

\u201cNext-generation modalities like LNPs are changing the world,\u201d said Tim Harkness, Founder and CEO at Unchained Labs. \u201cAll we think about every day is how to make the jobs of researchers developing these complex therapies easier, and we can\u2019t wait to get ALiS and ANP into the LNP labs that need them.\u201d\u00a0<\/span><\/p>\n

Investment funds affiliated with Carlyle<\/a>, which began backing Unchained Labs in 2021, invested capital to support the acquisition with participation from Unchained Labs management.\u00a0<\/span><\/p>\n

About Unchained Labs<\/b><\/p>\n

Here\u2019s the deal. We\u2019re all about helping biologics and gene therapy researchers break free from tools that just don\u2019t cut it. Unleashing problem-tackling products that make a huge difference in the real science they do every day. That\u2019s our mantra, our promise and we own it. We\u2019re located in Pleasanton, CA and can be found online at unchainedlabs.com\/jp<\/a>.\u00a0<\/span><\/p>\n

Contact:<\/b><\/p>\n

Taegen Clary
\nSVP of Marketing, Unchained Labs
\ntaegen.clary@unchainedlabs.com\/jp<\/a>
\n925.587.9806\u00a0<\/span><\/p>\n

Download PDF of the press release<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

July 17, 2023 \u2013 Pleasanton, CA \u2013 Unchained Labs, the life sciences company that\u2019s all about getting biologics and gene therapy researchers the right tools for the job, acquired Blacktrace Holdings today. For decades, Blacktrace\u2019s Dolomite microfluidics have been helping scientists with complex workflows. More recently, their Particle Works solutions are changing the game on…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,121],"tags":[],"class_list":["post-14094","post","type-post","status-publish","format-standard","hentry","category-uncategorized","category-news"],"acf":[],"yoast_head":"\nUnchained Labs goes all in on Lipid Nanoparticles, acquires Blacktrace Holdings! - unchainedlabs<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/unchainedlabs.com\/jp\/unchained-labs-goes-all-in-on-lipid-nanoparticles\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Unchained Labs goes all in on Lipid Nanoparticles, acquires Blacktrace Holdings! - unchainedlabs\" \/>\n<meta property=\"og:description\" content=\"July 17, 2023 \u2013 Pleasanton, CA \u2013 Unchained Labs, the life sciences company that\u2019s all about getting biologics and gene therapy researchers the right tools for the job, acquired Blacktrace Holdings today. 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